Tubulin modifying enzymes as goal for the therapy of tau-related ailments

Tubulin modifying enzymes as goal for the therapy of tau-related ailments

Tubulin modifying enzymes as aim for the remedy of tau-related illnesses

  • Inside the thoughts of victims with Alzheimer’s sickness (AD), the amount and dimension of microtubules (MTs) are significantly and selectively diminished. MTs are involved in a wide range of cell options, and defects of the microtubular system have emerged as a unifying hypothesis for the heterogeneous and variable medical exhibits of AD.
  • MTs orchestrate their fairly a couple of options by way of the spatiotemporal regulation of the binding of specialised microtubule-associated proteins (MAPs) and molecular motors. Covalent posttranslational modifications (PTMs) on the tubulin C-termini that protrude on the ground of MTs regulate the binding of these effectors.
  • In neurons, MAP tau may be very appreciable and its irregular dissociation from MTs inside the axon, cell mislocalization and hyperphosphorylation, are essential events leading to neuronal dying. Consequently, compounds concentrating on tau phosphorylation or aggregation are at current evaluated nevertheless their medical significance has not been demonstrated On this evaluation, we concentrate on the rising hyperlink between tubulin PTMs and tau dysfunction. In neurons, extreme ranges of glutamylation and detyrosination profoundly impression the physicochemical properties on the ground of MTs.
  • Moreover, in victims with early-onset progressive neurodegeneration, deleterious mutations in enzymes involved in modifying MTs on the ground have simply these days been acknowledged, underscoring the importance of this enzymatic gear in neurology. We postulate that pharmacologically concentrating on the tubulin-modifying enzymes holds promise as therapeutic technique for the remedy of neurodegenerative illnesses.

Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by concentrating on the essential enzymeMurA

Trivalent organoarsenicals equivalent to methylarsenite (MAs(III)) are considerably additional toxic than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) reveals essential antimicrobial train. Although MAs(III) and completely different organoarsenicals contribute to the worldwide arsenic biogeocycle, how they exert antibiotic-like properties is mainly unknown. To find out attainable targets of MAs(III), a genomic library of the gram-negative bacterium,

Shewanellaputrefaciens 200, was expressed in Escherichia coli with alternative for MAs(III) resistance. One clone contained the S. putrefaciensmurA gene (SpmurA), which catalyzes the first devoted step in peptidoglycan biosynthesis. Overexpression of SpmurA conferred MAs(III) resistance to E. coli.

Purified SpMurA was inhibited by MAs(III), phenylarsenite (PhAs(III)) or the phosphonate antibiotic fosfomycin nevertheless not by inorganic As(III). Fosfomycin inhibits MurA by binding to a conserved residue that corresponds to Cys117 in SpMurA. A C117D mutant was proof towards fosfomycin nevertheless remained delicate to MAs(III), indicating that the two compounds have completely completely different mechanisms of movement. New inhibitors of peptidoglycan biosynthesis are extraordinarily wished as antimicrobial treatment, and organoarsenicals characterize a new area for the occasion of novel compounds for combating the specter of antibiotic resistance.

nmr-spectrometers
nmr-spectrometers

Biochemistry of prenylated-FMN enzymes

  • The reversible (de)carboxylation of unsaturated carboxylic acids is carried out by the UbiX-UbiD system, ubiquitously present in microbes. The biochemical basis of this tough response has simply these days been uncovered by the invention of the UbiD cofactor, prenylated FMN (prFMN).
  • This carefully modified flavin is synthesized by the flavinprenyltransferaseUbiX, which catalyzes the non-metal dependent prenyl swap from dimethylallyl(pyro)phosphate (DMAP(P)) to the flavin N5 and C6 positions, making a fourth non-aromatic ring. Following prenylation, prFMN undergoes oxidative maturation to sort the iminium species required for UbiD train. prFMNiminium acts as a prostethic group and is definite by means of metal ion mediated interactions between UbiD and the prFMNiminium phosphate moiety.
  • The modified isoalloxazine ring is place adjoining to the E(D)-R-E UbiD signature sequent motif. The fungal ferulic acid decarboxylase Fdc from Aspergillus niger has emerged as a UbiD-model system, and has yielded atomic diploma notion into the prFMNiminium mediated (de)carboxylation. A wealth of knowledge now helps a mechanism reliant on reversible 1,Three dipolar cycloaddition between substrate and cofactor for this enzyme.
  • This poses the intriguing question whether or not or not an identical mechanism is utilized by all UbiD enzymes, significantly those that act as carboxylases on inherently more durable substrates equivalent to phenylphosphate or benzene/naphthalene. Definitely, considerable variability in the case of oligomerization, space motion and energetic website online development is now reported for the UbiD family.

Bovine SUMO- activating enzyme subunit 1, SAE1 ELISA KIT

ELI-18883b 96 Tests
EUR 1113.6

SAE1 SUMO1 Activating Enzyme Subunit 1 Human Recombinant Protein

PROTQ9UBE0 Regular: 10ug
EUR 380.4
Description: SAE1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 378 amino acids (1-346 a.a.) and having a molecular mass of 42.2 kDa. The SAE1 is fused to 32 amino acid T7-Tag at N-terminus and purified by proprietary chromatographic techniques. _x000D_

Sumo1 Activating Enzyme Subunit 1 Antibody

20-abx115897
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Mouse SUMO- activating enzyme subunit 2, Uba2 ELISA KIT

ELI-39249m 96 Tests
EUR 1038

Human SUMO- activating enzyme subunit 2, UBA2 ELISA KIT

ELI-13499h 96 Tests
EUR 988.8

SUMO1 Activating Enzyme Subunit 1 (Recombinant)

20-abx073779
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Human SUMO-activating enzyme subunit 1 (SAE1)

1-CSB-EP883359HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human SUMO-activating enzyme subunit 1(SAE1) expressed in E.coli

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx135880
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx237577-100ug 100 ug
EUR 610.8

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx241829
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx241917
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx321167
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx332268-100ul 100 ul
EUR 510

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-400ul 400 ul
EUR 627.6

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-80l 80 µl
EUR 343.2

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx329440
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx430292-200ul 200 ul
EUR 460.8

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx008366
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03556 2µg Ask for price

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03557 10µg Ask for price

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03558 1mg Ask for price

Cow SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520274-96tests 96 tests
EUR 1093.2

Rat SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520277-96tests 96 tests
EUR 801.6

Human SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx251614-96tests 96 tests
EUR 801.6

Mouse SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520276-96tests 96 tests
EUR 801.6

Human SAE1(SUMO-activating enzyme subunit 1) ELISA Kit

EH2266 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human SAE1/ SUMO-activating enzyme subunit 1 ELISA Kit

E2210Hu 1 Kit
EUR 685.2

Sae1 ELISA Kit| Rat SUMO-activating enzyme subunit 1 ELISA Kit

EF019390 96 Tests
EUR 826.8

Sae1 ELISA Kit| Mouse SUMO-activating enzyme subunit 1 ELISA Ki

EF016320 96 Tests
EUR 826.8

SAE1 ELISA Kit| Bovine SUMO-activating enzyme subunit 1 ELISA K

EF011944 96 Tests
EUR 826.8

NEDD8 Activating Enzyme E1 Subunit 1 (Recombinant)

20-abx073743
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx213715
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx214286
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx122107-100ug 100 ug
EUR 469.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx322625
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Nedd8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx114040
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-400ul 400 ul
EUR 627.6

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-80l 80 µl
EUR 343.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-400ul 400 ul
EUR 627.6

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-80l 80 µl
EUR 343.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx003153
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-400ul 400 ul
EUR 627.6

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-80l 80 µl
EUR 343.2

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx430135-200ul 200 ul
EUR 460.8

UBA2 Antibody / SUMO-activating enzyme subunit 2 / SAE2

RQ4241 100 ug
EUR 356.15
Description: Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene. Posttranslational modification of proteins by the addition of the small protein SUMO, or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins

UBA2 Antibody / SUMO-activating enzyme subunit 2 / SAE2

RQ5505 100 ug
EUR 356.15
Description: Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene. Posttranslational modification of proteins by the addition of the small protein SUMO, or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins

NAE1 NEDD8 Activating Enzyme E1 Subunit 1 Human Recombinant Protein

PROTQ13564 Regular: 10ug
EUR 380.4
Description: NAE1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 557 amino acids (1-534) and having a molecular mass of 62.7kDa.;NAE1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SUMO-Activating Enzyme Subunit 1 (AOS1) Antibody

20-abx013214
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Human SUMO-activating enzyme subunit 2 (UBA2)

1-CSB-EP890664HU
  • EUR 524.40
  • EUR 285.60
  • EUR 1852.80
  • EUR 783.60
  • EUR 1234.80
  • EUR 355.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human SUMO-activating enzyme subunit 2(UBA2) expressed in E.coli

ELISA kit for Human SUMO-activating enzyme subunit 1

EK4587 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human SUMO-activating enzyme subunit 1 in samples from serum, plasma, tissue homogenates and other biological fluids.

E1 Ubiquitin Activating Enzyme Antibody

DF13630 100ul
EUR 420

mlN4924 (NEDD8 activating enzyme inhibitor)

SIH-331-1MG 1 mg
EUR 1204.8
Description: The substance mlN4924 is a nedd8 activating enzyme inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is soluble in 10 mg/ml DMSO.

mlN4924 (NEDD8 activating enzyme inhibitor)

SIH-331-200UG 200 µg
EUR 374.4
Description: The substance mlN4924 is a nedd8 activating enzyme inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is soluble in 10 mg/ml DMSO.

UFM1 activating enzyme Recombinant Protein

92-228 0.05 mg
EUR 651.3
Description: UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. UBA5 is located primarily in cytoplasm, while it generally localizes to the nucleus in presence of SUMO2.

Anti-Uba5/Ufm1 Activating Enzyme Antibody

A06385 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Uba5 Antibody (UBA5) detection.tested for WB in Human, Mouse, Rat.

UBA1 Antibody / E1 Ubiquitin activating enzyme

F54754-0.08ML 0.08 ml
EUR 140.25
Description: UBE1 / UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding the same protein, but with different 5' UTR.

UBA1 Antibody / E1 Ubiquitin activating enzyme

F54754-0.4ML 0.4 ml
EUR 322.15
Description: UBE1 / UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding the same protein, but with different 5' UTR.

Rat E1/ubiquitin activating enzyme ELISA kit

E02E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E1/ubiquitin activating enzyme ELISA kit

E02E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E1/ubiquitin activating enzyme ELISA kit

E02E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E1/ubiquitin activating enzyme ELISA kit

E08E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E1/ubiquitin activating enzyme ELISA kit

E08E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E1/ubiquitin activating enzyme ELISA kit

E08E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E1/ubiquitin activating enzyme ELISA kit

E07E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E1/ubiquitin activating enzyme ELISA kit

E07E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E1/ubiquitin activating enzyme ELISA kit

E07E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-Ubiquitin Activating Enzyme E1 Antibody

A02810 500ug
EUR 518.4
Description: Rabbit Polyclonal Ubiquitin Activating Enzyme E1 Antibody. Validated in IHC, WB and tested in Human.

Goat E1/ubiquitin activating enzyme ELISA kit

E06E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E1/ubiquitin activating enzyme ELISA kit

E06E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E1/ubiquitin activating enzyme ELISA kit

E06E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

abx239143-100ug 100 ug
EUR 661.2

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx324789
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

abx330573-100ul 100 ul
EUR 510

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

abx037966-100ug 100 ug
EUR 469.2

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx003250
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx008367
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx013243
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Mouse E1/ubiquitin activating enzyme ELISA kit

E03E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E1/ubiquitin activating enzyme ELISA kit

E03E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E1/ubiquitin activating enzyme ELISA kit

E03E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E1/ubiquitin activating enzyme ELISA kit

E01E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E1/ubiquitin activating enzyme ELISA kit

E01E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E1/ubiquitin activating enzyme ELISA kit

E01E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human recombinant Ubiquitin Activating Enzyme E1

6429-50 each
EUR 542.4

Rabbit E1/ubiquitin activating enzyme ELISA kit

E04E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E1/ubiquitin activating enzyme ELISA kit

E04E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E1/ubiquitin activating enzyme ELISA kit

E04E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E1/ubiquitin activating enzyme ELISA kit

E09E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E1/ubiquitin activating enzyme ELISA kit

E09E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E1/ubiquitin activating enzyme ELISA kit

E09E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx242011
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx242036
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx214161
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx214162
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx327721
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

abx028137-400ul 400 ul
EUR 627.6

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

abx028137-80l 80 µl
EUR 343.2

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx126752
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx338621
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx116488
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Anti-E1 Ubiquitin Activating Enzyme/UBA1 Antibody

PB9904 100ug/vial
EUR 352.8

Guinea pig E1/ubiquitin activating enzyme ELISA kit

E05E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E1/ubiquitin activating enzyme ELISA kit

E05E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E1/ubiquitin activating enzyme ELISA kit

E05E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody (HRP)

20-abx338233
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rabbit Ubiquitin- like modifier- activating enzyme 1, UBA1 ELISA

ELI-28477Ra 96 Tests
EUR 1113.6

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody (FITC)

20-abx338234
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) ELISA Kit

abx384056-96tests 96 tests
EUR 1093.2

Human Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) ELISA Kit

abx595612-96tests 96 tests
EUR 764.4

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody (Biotin)

20-abx338235
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ubiquitin-Like Modifier Activating Enzyme 3 (Recombinant)

20-abx073328
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ubiquitin-Like Modifier Activating Enzyme 5 (Recombinant)

20-abx073800
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

abx239162-100ug 100 ug
EUR 661.2

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

20-abx175012
  • EUR 978.00
  • EUR 510.00
  • 1 mg
  • 200 ug

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

abx122278-100ug 100 ug
EUR 469.2

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

20-abx324412
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

abx331555-100ul 100 ul
EUR 510

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

abx027867-400ul 400 ul
EUR 627.6

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

abx027867-80l 80 µl
EUR 343.2

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

20-abx128901
  • EUR 493.20
  • EUR 159.60
  • EUR 1378.80
  • EUR 678.00
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

20-abx129740
  • EUR 510.00
  • EUR 159.60
  • EUR 1412.40
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

20-abx130267
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

20-abx008599
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

abx011667-100ul 100 ul
EUR 493.2

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Antibody

20-abx013244
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody

20-abx305847
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ubiquitin-Like Modifier Activating Enzyme 2 (UBA2) Antibody

20-abx116489
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5) Antibody

20-abx116490
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Ubiquitin-Like Modifier Activating Enzyme 6 (UBA6) Antibody

20-abx116491
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) Antibody

20-abx116492
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

E1 Ubiquitin Activating Enzyme recombinant monoclonal antibody

A5836 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human E1 Ubiquitin Activating Enzyme for WB, IHC,ELISA

Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L)

4-RPB027Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Ubiquitin Activating Enzyme E1 Like Protein expressed in: E.coli

Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L)

4-RPB027Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Ubiquitin Activating Enzyme E1 Like Protein expressed in: E.coli

Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L)

4-RPB027Ra01
  • EUR 539.33
  • EUR 267.60
  • EUR 1692.48
  • EUR 644.16
  • EUR 1168.32
  • EUR 436.80
  • EUR 4051.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Ubiquitin Activating Enzyme E1 Like Protein expressed in: E.coli

Recombinant Ubiquitin Like Modifier Activating Enzyme 5 (UBA5)

4-RPG155Mu01
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Ubiquitin Like Modifier Activating Enzyme 5 expressed in: E.coli

Rat Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Protein

20-abx166200
  • EUR 760.80
  • EUR 326.40
  • EUR 2281.20
  • EUR 895.20
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody (HRP)

20-abx305848
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Mouse Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Protein

20-abx167964
  • EUR 828.00
  • EUR 343.20
  • EUR 2548.80
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Protein

20-abx166198
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody (FITC)

20-abx305849
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Pig Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) ELISA Kit

abx361494-96tests 96 tests
EUR 990

Dog Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E08U0040-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E08U0040-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E08U0040-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E02U0040-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E02U0040-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E02U0040-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E07U0040-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E07U0040-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E07U0040-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) CLIA Kit

abx197875-96tests 96 tests
EUR 990

Goat Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E06U0040-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E06U0040-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E06U0040-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Ubiquitin Like Modifier Activating Enzyme 7 (UBA7) Antibody (Biotin)

20-abx305850
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) ELISA Kit

abx253339-96tests 96 tests
EUR 904.8

Dog Ubiquitin like modifier activating enzyme ATG7(ATG7) ELISA kit

E08U0034-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Ubiquitin like modifier activating enzyme ATG7(ATG7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ubiquitin like modifier activating enzyme ATG7(ATG7) ELISA kit

E08U0034-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Ubiquitin like modifier activating enzyme ATG7(ATG7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Ubiquitin like modifier activating enzyme ATG7(ATG7) ELISA kit

E08U0034-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Ubiquitin like modifier activating enzyme ATG7(ATG7) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E03U0040-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E03U0040-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E03U0040-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E01U0040-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E01U0040-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Ubiquitin like modifier activating enzyme 5(UBA5) ELISA kit

E01U0040-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Ubiquitin like modifier activating enzyme 5(UBA5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mapping enzyme-substrate interactions: its potential to assessment the mechanism of enzymes

With the rise of the need to make use of additional sustainable processes for the commerce in our society, the modeling of enzymes has flip into important to completely comprehend their mechanism of movement and use this info to enhance and design their properties. A great deal of methods to assessment enzymes computationally exist they often have been categorized on sequence-based, structure-based, and the additional new artificial intelligence-based ones.

Albeit the abundance of methods to help predict the carry out of an enzyme, molecular modeling is important when attempting to know the enzyme mechanism, as they function to correlate atomistic information with experimental info. Amongst them, methods that simulate the system dynamics at a molecular mechanics diploma of precept (classical strain fields) have confirmed to produce a whole analysis.

On this information chapter, we’ll analyze these strategies, emphasizing the importance of actual modeling of enzyme-substrate interactions. In the long term, a fast clarification of the transference of the information from evaluation analysis to the commerce is given accompanied with two examples of family enzymes the place their modeling has helped their exploitation.

Extreme-throughput expertise of product profiles for arabinoxylan-active enzymes from metagenomes

  • Metagenomics is an thrilling completely different to hunt for carbohydrate-active enzymes from a wide range of sources. Generally, metagenomics reveals dozens of putative catalysts that require sensible characterization for extra utility in industrial processes. Extreme-throughput screening methods applicable with sufficient pure substrates are important for an right sensible elucidation of substrate preferences.
  • Based mostly totally on DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) analysis of enzymatic response merchandise, we generated product profiles to consequently infer substrate cleavage positions, ensuing inside the expertise of enzymatic degradation maps.
  • Product profiles had been produced in high-throughput for arabinoxylan (AX)-active enzymes belonging to the glycoside hydrolase households GH43 (subfamilies 2 (MG432), 7 (MG437) and 28 (MG4328)) and GH8 (MG8) starting from twelve (arabino)xylo-oligosaccharides.
  • These enzymes had been discovered by way of sensible metagenomic analysis of faeces from the North American beaver (Castor canadensis). This work reveals how enzyme loading alters the product profiles produced by all enzymes studied and gives notion into AX degradation patterns revealing sequential substrate preferences of AX-active enzymes.
  • SignificanceArabinoxylan is very found inside the hemicellulosic fractions of rice straw, corn cobs and rice husk. Altering arabinoxylan into (arabino)xylo-oligosaccharides as added value merchandise which may be utilized in meals, feed, and cosmetics presents a sustainable and monetary completely different for the biorefinery industries. An atmosphere pleasant and worthwhile AX degradation requires a set of enzymes with particular traits.

As a result of this truth, enzyme discovery and analysis of substrate preferences is of utmost significance. Beavers, as buyers of woody biomass are a promising provide of a repertoire of enzymes able to deconstruct hemicelluloses into soluble oligosaccharides. Extreme-throughput analysis of oligosaccharide profiles produced by these enzymes will assist inside the assortment of most likely probably the most relevant enzymes for the biorefinery.

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