Tubulin modifying enzymes as goal for the therapy of tau-related ailments

Tubulin modifying enzymes as goal for the therapy of tau-related ailments

Tubulin modifying enzymes as aim for the remedy of tau-related illnesses

  • Inside the thoughts of victims with Alzheimer’s sickness (AD), the amount and dimension of microtubules (MTs) are significantly and selectively diminished. MTs are involved in a wide range of cell options, and defects of the microtubular system have emerged as a unifying hypothesis for the heterogeneous and variable medical exhibits of AD.
  • MTs orchestrate their fairly a couple of options by way of the spatiotemporal regulation of the binding of specialised microtubule-associated proteins (MAPs) and molecular motors. Covalent posttranslational modifications (PTMs) on the tubulin C-termini that protrude on the ground of MTs regulate the binding of these effectors.
  • In neurons, MAP tau may be very appreciable and its irregular dissociation from MTs inside the axon, cell mislocalization and hyperphosphorylation, are essential events leading to neuronal dying. Consequently, compounds concentrating on tau phosphorylation or aggregation are at current evaluated nevertheless their medical significance has not been demonstrated On this evaluation, we concentrate on the rising hyperlink between tubulin PTMs and tau dysfunction. In neurons, extreme ranges of glutamylation and detyrosination profoundly impression the physicochemical properties on the ground of MTs.
  • Moreover, in victims with early-onset progressive neurodegeneration, deleterious mutations in enzymes involved in modifying MTs on the ground have simply these days been acknowledged, underscoring the importance of this enzymatic gear in neurology. We postulate that pharmacologically concentrating on the tubulin-modifying enzymes holds promise as therapeutic technique for the remedy of neurodegenerative illnesses.

Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by concentrating on the essential enzymeMurA

Trivalent organoarsenicals equivalent to methylarsenite (MAs(III)) are considerably additional toxic than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) reveals essential antimicrobial train. Although MAs(III) and completely different organoarsenicals contribute to the worldwide arsenic biogeocycle, how they exert antibiotic-like properties is mainly unknown. To find out attainable targets of MAs(III), a genomic library of the gram-negative bacterium,

Shewanellaputrefaciens 200, was expressed in Escherichia coli with alternative for MAs(III) resistance. One clone contained the S. putrefaciensmurA gene (SpmurA), which catalyzes the first devoted step in peptidoglycan biosynthesis. Overexpression of SpmurA conferred MAs(III) resistance to E. coli.

Purified SpMurA was inhibited by MAs(III), phenylarsenite (PhAs(III)) or the phosphonate antibiotic fosfomycin nevertheless not by inorganic As(III). Fosfomycin inhibits MurA by binding to a conserved residue that corresponds to Cys117 in SpMurA. A C117D mutant was proof towards fosfomycin nevertheless remained delicate to MAs(III), indicating that the two compounds have completely completely different mechanisms of movement. New inhibitors of peptidoglycan biosynthesis are extraordinarily wished as antimicrobial treatment, and organoarsenicals characterize a new area for the occasion of novel compounds for combating the specter of antibiotic resistance.

nmr-spectrometers
nmr-spectrometers

Biochemistry of prenylated-FMN enzymes

  • The reversible (de)carboxylation of unsaturated carboxylic acids is carried out by the UbiX-UbiD system, ubiquitously present in microbes. The biochemical basis of this tough response has simply these days been uncovered by the invention of the UbiD cofactor, prenylated FMN (prFMN).
  • This carefully modified flavin is synthesized by the flavinprenyltransferaseUbiX, which catalyzes the non-metal dependent prenyl swap from dimethylallyl(pyro)phosphate (DMAP(P)) to the flavin N5 and C6 positions, making a fourth non-aromatic ring. Following prenylation, prFMN undergoes oxidative maturation to sort the iminium species required for UbiD train. prFMNiminium acts as a prostethic group and is definite by means of metal ion mediated interactions between UbiD and the prFMNiminium phosphate moiety.
  • The modified isoalloxazine ring is place adjoining to the E(D)-R-E UbiD signature sequent motif. The fungal ferulic acid decarboxylase Fdc from Aspergillus niger has emerged as a UbiD-model system, and has yielded atomic diploma notion into the prFMNiminium mediated (de)carboxylation. A wealth of knowledge now helps a mechanism reliant on reversible 1,Three dipolar cycloaddition between substrate and cofactor for this enzyme.
  • This poses the intriguing question whether or not or not an identical mechanism is utilized by all UbiD enzymes, significantly those that act as carboxylases on inherently more durable substrates equivalent to phenylphosphate or benzene/naphthalene. Definitely, considerable variability in the case of oligomerization, space motion and energetic website online development is now reported for the UbiD family.

Bovine SUMO- activating enzyme subunit 1, SAE1 ELISA KIT

ELI-18883b 96 Tests
EUR 1113.6

Sae1 (GFP-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1)

MG205319 10 µg Ask for price

Sae1 (untagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), (10ug)

MC205310 10 µg Ask for price

Sae1 (untagged ORF) - Rat SUMO1 activating enzyme subunit 1 (Sae1), (10 ug)

RN207212 10 µg Ask for price

Sae1 (Myc-DDK-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1)

MR205319 10 µg Ask for price

SUMO-1 Activating Enzyme Subunit 1 (SAE1) Rabbit anti-Human Polyclonal Antibody

GWB-2CED11 0.05 mg Ask for price

SAE1 (untagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1

SC116689 10 µg Ask for price

Sae1 (Myc-DDK-tagged ORF) - Rat SUMO1 activating enzyme subunit 1 (Sae1), (10 ug)

RR207212 10 µg Ask for price

Sae1 (untagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), transcript variant 3

MC227056 10 µg Ask for price

Sae1 (untagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), transcript variant 2

MC227211 10 µg Ask for price

SAE1 (GFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1

RG227950 10 µg Ask for price

SAE1 (GFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1

RG201820 10 µg Ask for price

SAE1 (GFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2

RG226908 10 µg Ask for price

SAE1 (GFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3

RG226930 10 µg Ask for price

Lenti ORF clone of Sae1 (mGFP-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1)

MR205319L4 10 µg Ask for price

SAE1 SUMO1 Activating Enzyme Subunit 1 Human Recombinant Protein

PROTQ9UBE0 Regular: 10ug
EUR 380.4
Description: SAE1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 378 amino acids (1-346 a.a.) and having a molecular mass of 42.2 kDa. The SAE1 is fused to 32 amino acid T7-Tag at N-terminus and purified by proprietary chromatographic techniques. _x000D_

SAE1 (untagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3, mRNA

SC326542 10 µg Ask for price

SAE1 (untagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2, mRNA

SC326551 10 µg Ask for price

SAE1 (Myc-DDK-tagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1

RC201820 10 µg Ask for price

SAE1 (Myc-DDK-tagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1

RC227950 10 µg Ask for price

Lenti ORF clone of Sae1 (Myc-DDK-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1)

MR205319L3 10 µg Ask for price

Rabbit Polyclonal antibody to SAE1 (SUMO1 activating enzyme subunit 1)

TA308733 100 µl Ask for price

Sae1 (myc-DDK-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), transcript variant 3

MR229267 10 µg Ask for price

Sae1 (myc-DDK-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), transcript variant 2

MR229422 10 µg Ask for price

SAE1 (Myc-DDK-tagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2

RC226908 10 µg Ask for price

SAE1 (Myc-DDK-tagged)-Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3

RC226930 10 µg Ask for price

Lenti ORF clone of Sae1 (mGFP-tagged ORF) - Rat SUMO1 activating enzyme subunit 1 (Sae1), (10 ug)

RR207212L4 10 µg Ask for price

Lenti ORF clone of Sae1 (Myc-DDK-tagged ORF) - Rat SUMO1 activating enzyme subunit 1 (Sae1), (10 ug)

RR207212L3 10 µg Ask for price

Lenti ORF particles, Sae1 (GFP-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), 200ul, >10^7 TU/mL

MR205319L4V 200 µl Ask for price

Lenti ORF particles, Sae1 (GFP-tagged ORF) - Rat SUMO1 activating enzyme subunit 1 (Sae1), 200ul, >10^7 TU/mL

RR207212L4V 200 µl Ask for price

Lenti ORF particles, Sae1 (Myc-DDK-tagged) - Mouse SUMO1 activating enzyme subunit 1 (Sae1), 200ul, >10^7 TU/mL

MR205319L3V 200 µl Ask for price

Lenti ORF particles, Sae1 (Myc-DDK-tagged ORF) - Rat SUMO1 activating enzyme subunit 1 (Sae1), 200ul, >10^7 TU/mL

RR207212L3V 200 µl Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, mGFP tagged

RC201820L2 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, mGFP tagged

RC201820L4 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, mGFP tagged

RC227950L2 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, mGFP tagged

RC227950L4 10 µg Ask for price

Lenti ORF particles, SAE1 (mGFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC201820L2V 200 µl Ask for price

Lenti ORF particles, SAE1 (mGFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC201820L4V 200 µl Ask for price

Lenti ORF particles, SAE1 (mGFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC227950L2V 200 µl Ask for price

Lenti ORF particles, SAE1 (mGFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC227950L4V 200 µl Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2, mGFP tagged

RC226908L4 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3, mGFP tagged

RC226930L4 10 µg Ask for price

Lenti ORF particles, SAE1 (Myc-DDK tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC201820L1V 200 µl Ask for price

Lenti ORF particles, SAE1 (Myc-DDK tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC201820L3V 200 µl Ask for price

Lenti ORF particles, SAE1 (Myc-DDK tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC227950L1V 200 µl Ask for price

Lenti ORF particles, SAE1 (Myc-DDK tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, 200ul, >10^7 TU/mL

RC227950L3V 200 µl Ask for price

Lenti ORF particles, SAE1 (mGFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2, 200ul, >10^7 TU/mL

RC226908L4V 200 µl Ask for price

Lenti ORF particles, SAE1 (mGFP-tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3, 200ul, >10^7 TU/mL

RC226930L4V 200 µl Ask for price

Lenti ORF particles, SAE1 (Myc-DDK tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2, 200ul, >10^7 TU/mL

RC226908L3V 200 µl Ask for price

Lenti ORF particles, SAE1 (Myc-DDK tagged) - Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3, 200ul, >10^7 TU/mL

RC226930L3V 200 µl Ask for price

Uba2 (GFP-tagged) - Mouse SUMO1 activating enzyme subunit 2 (Sae2)

MG209672 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, Myc-DDK-tagged

RC201820L1 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, Myc-DDK-tagged

RC201820L3 10 µg Ask for price

3`UTR clone of SUMO1 activating enzyme subunit 1 (SAE1) transcript variant 1 for miRNA target validation

SC214320 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, Myc-DDK-tagged

RC227950L1 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 1, Myc-DDK-tagged

RC227950L3 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 2, Myc-DDK-tagged

RC226908L3 10 µg Ask for price

Lenti ORF clone of Human SUMO1 activating enzyme subunit 1 (SAE1), transcript variant 3, Myc-DDK-tagged

RC226930L3 10 µg Ask for price

3`UTR clone of SUMO1 activating enzyme subunit 1 (SAE1) transcript variant 2 for miRNA target validation

SC213882 10 µg Ask for price

3`UTR clone of SUMO1 activating enzyme subunit 1 (SAE1) transcript variant 3 for miRNA target validation

SC214830 10 µg Ask for price

SUMO-1 Activating Enzyme Subunit 2 (UBA2/SAE2) Rabbit anti-Human Polyclonal (aa160-210) Antibody

GWB-925827 0.05 mg Ask for price

Human SUMO-activating enzyme subunit 1 (SAE1)

1-CSB-EP883359HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human SUMO-activating enzyme subunit 1(SAE1) expressed in E.coli

Mouse SUMO- activating enzyme subunit 2, Uba2 ELISA KIT

ELI-39249m 96 Tests
EUR 1038

Human SUMO- activating enzyme subunit 2, UBA2 ELISA KIT

ELI-13499h 96 Tests
EUR 988.8

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx135880
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  • 100 ul
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  • 20 ul
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SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx008366
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  • 100 ul
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SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-400ul 400 ul
EUR 627.6

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-80l 80 µl
EUR 343.2

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx332268-100ul 100 ul
EUR 510

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx329440
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  • 100 ug
  • 50 ug

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx430292-200ul 200 ul
EUR 460.8

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx237577-100ug 100 ug
EUR 610.8

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx241829
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  • 100 ul
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SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx241917
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  • 100 ul
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SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx321167
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  • 100 ul
  • 50 ul

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-400l 400 µl
EUR 518.75

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx241829-96tests 96 tests
EUR 250

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx241917-96tests 96 tests
EUR 250

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx237577-100g 100 µg
EUR 350

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx135880-01mg 0.1 mg
EUR 175

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx321167-100g 100 µg
EUR 350

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx321167-50g 50 µg
EUR 250

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx402587-100g 100 µg
EUR 400

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx402587-200g 200 µg Ask for price

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx402587-25g 25 µg
EUR 287.5

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx329440-100g 100 µg Ask for price

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx329440-20g 20 µg
EUR 187.5

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx329440-50g 50 µg
EUR 250

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx430292-200l 200 µl
EUR 387.5

Sumo1 Activating Enzyme Subunit 1 Antibody

20-abx115897
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  • 150 ul
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Sumo1 Activating Enzyme Subunit 1 Antibody

abx115897-100g 100 µg Ask for price

Sumo1 Activating Enzyme Subunit 1 Antibody

abx115897-10g 10 µg
EUR 612.5

Sumo1 Activating Enzyme Subunit 1 Antibody

abx115897-200g 200 µg Ask for price

SUMO1 Activating Enzyme Subunit 1 (Recombinant)

20-abx073779
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  • 10 ug
  • 1 mg
  • 2 µg

Human SUMO-Activating Enzyme Subunit 1 (SAE1) Protein

abx073779-100tests 100 tests
EUR 225

Human SUMO-Activating Enzyme Subunit 1 (SAE1) Protein

abx073779-1920tests 1920 tests
EUR 6575

Human SUMO-Activating Enzyme Subunit 1 (SAE1) Protein

abx073779-400tests 400 tests
EUR 325

Recombinant Human SUMO-activating enzyme subunit 1(SAE1)

AP77049 1mg
EUR 1978

Recombinant Human SUMO-activating enzyme subunit 1 (SAE1)

CSB-EP883359HU 4713 mg Ask for price

Recombinant Human SUMO-activating enzyme subunit 1 (SAE1)

RPC23683-100ug 100ug
EUR 460.9

Recombinant Human SUMO-activating enzyme subunit 1 (SAE1)

RPC23683-1mg 1mg
EUR 2237.8

Recombinant Human SUMO-activating enzyme subunit 1 (SAE1)

RPC23683-20ug 20ug
EUR 258.7

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03556 2µg Ask for price

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03557 10µg Ask for price

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03558 1mg Ask for price

SUMO1 Activating Enzyme Subunit 1 Human Recombinant

rAP-1398 Inquiry Ask for price

Cow SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520274-96tests 96 tests
EUR 1093.2

Rat SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520277-96tests 96 tests
EUR 801.6

Rat SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

RK14711 96T
EUR 280

Cow SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520274-1096tests 10 × 96 tests Ask for price

Cow SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520274-596tests 5 × 96 tests Ask for price

Human SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx251614-96tests 96 tests
EUR 801.6

Mouse SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520276-96tests 96 tests
EUR 801.6

Mouse SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

RK13587 96T
EUR 280

Human SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

RK12113 96T
EUR 280

Rat Sae1 / SUMO-activating enzyme subunit 1 ELISA Kit

E3292r 96T
EUR 796

Human SAE1(SUMO-activating enzyme subunit 1) ELISA Kit

EH2266 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human SAE1/ SUMO-activating enzyme subunit 1 ELISA Kit

E2210Hu 1 Kit
EUR 515
Description: AOS1,SUA1,UBLE1A,Ubiquitin-like 1-activating enzyme E1A

Human SAE1 / SUMO-activating enzyme subunit 1 ELISA Kit

E3292h 96T
EUR 736

Mouse Sae1 / SUMO-activating enzyme subunit 1 ELISA Kit

E3292m 96T
EUR 776

Bovine SAE1 / SUMO-activating enzyme subunit 1 ELISA Kit

E3292b 96T
EUR 900

Sae1 ELISA Kit| Rat SUMO-activating enzyme subunit 1 ELISA Kit

EF019390 96 Tests
EUR 826.8

Sae1 ELISA Kit| Mouse SUMO-activating enzyme subunit 1 ELISA Ki

EF016320 96 Tests
EUR 826.8

SAE1 ELISA Kit| Bovine SUMO-activating enzyme subunit 1 ELISA K

EF011944 96 Tests
EUR 826.8

NEDD8 Activating Enzyme E1 Subunit 1 (Recombinant)

20-abx073743
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  • 10 ug
  • 1 mg
  • 2 µg

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-400ul 400 ul
EUR 627.6

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-80l 80 µl
EUR 343.2

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx430135-200ul 200 ul
EUR 460.8

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-400l 400 µl
EUR 518.75

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx430135-200l 200 µl
EUR 387.5

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx122107-100ug 100 ug
EUR 469.2

Nedd8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx114040
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  • 150 ul
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NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-400ul 400 ul
EUR 627.6

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-80l 80 µl
EUR 343.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-400ul 400 ul
EUR 627.6

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-80l 80 µl
EUR 343.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx003153
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NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx213715
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NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx214286
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  • 100 ul
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NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx322625
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NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx003153-100l 100 µl
EUR 400

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx003153-20l 20 µl
EUR 175

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx003153-50l 50 µl
EUR 275

Nedd8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx114040-100l 100 µl
EUR 612.5

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx213715-100l 100 µl
EUR 250

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx214286-100tests 100 tests
EUR 350

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx214286-200tests 200 tests Ask for price

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx214286-50tests 50 tests
EUR 250

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx122107-100l 100 µl Ask for price

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx122107-20l 20 µl
EUR 337.5

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx122107-50l 50 µl Ask for price

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-100g 100 µg
EUR 281.25

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-400l 400 µl
EUR 518.75

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx322625-100g 100 µg
EUR 350

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx322625-50g 50 µg
EUR 250

NEDD8 Activating Enzyme E1 Subunit 1 Human Recombinant

rAP-1383 Inquiry Ask for price

Human NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Protein

abx073743-100tests 100 tests
EUR 225

Human NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Protein

abx073743-1920tests 1920 tests
EUR 6575

Human NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Protein

abx073743-400tests 400 tests
EUR 325

UBA2 Antibody / SUMO-activating enzyme subunit 2 / SAE2

RQ5505 100 ug
EUR 356.15
Description: Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene. Posttranslational modification of proteins by the addition of the small protein SUMO, or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins

UBA2 Antibody / SUMO-activating enzyme subunit 2 / SAE2

RQ4241 100 ug
EUR 356.15
Description: Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene. Posttranslational modification of proteins by the addition of the small protein SUMO, or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins

Rat NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) ELISA Kit

abx552577-96tests 96 tests
EUR 737.5

NAE1 NEDD8 Activating Enzyme E1 Subunit 1 Human Recombinant Protein

PROTQ13564 Regular: 10ug
EUR 380.4
Description: NAE1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 557 amino acids (1-534) and having a molecular mass of 62.7kDa.;NAE1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Nae1 (untagged) - Mouse NEDD8 activating enzyme E1 subunit 1 (Nae1), (10ug)

MC201567 10 µg Ask for price

Nae1 (untagged ORF) - Rat NEDD8 activating enzyme E1 subunit 1 (Nae1), (10 ug)

RN205725 10 µg Ask for price

Mapping enzyme-substrate interactions: its potential to assessment the mechanism of enzymes

With the rise of the need to make use of additional sustainable processes for the commerce in our society, the modeling of enzymes has flip into important to completely comprehend their mechanism of movement and use this info to enhance and design their properties. A great deal of methods to assessment enzymes computationally exist they often have been categorized on sequence-based, structure-based, and the additional new artificial intelligence-based ones.

Albeit the abundance of methods to help predict the carry out of an enzyme, molecular modeling is important when attempting to know the enzyme mechanism, as they function to correlate atomistic information with experimental info. Amongst them, methods that simulate the system dynamics at a molecular mechanics diploma of precept (classical strain fields) have confirmed to produce a whole analysis.

On this information chapter, we’ll analyze these strategies, emphasizing the importance of actual modeling of enzyme-substrate interactions. In the long term, a fast clarification of the transference of the information from evaluation analysis to the commerce is given accompanied with two examples of family enzymes the place their modeling has helped their exploitation.

Extreme-throughput expertise of product profiles for arabinoxylan-active enzymes from metagenomes

  • Metagenomics is an thrilling completely different to hunt for carbohydrate-active enzymes from a wide range of sources. Generally, metagenomics reveals dozens of putative catalysts that require sensible characterization for extra utility in industrial processes. Extreme-throughput screening methods applicable with sufficient pure substrates are important for an right sensible elucidation of substrate preferences.
  • Based mostly totally on DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) analysis of enzymatic response merchandise, we generated product profiles to consequently infer substrate cleavage positions, ensuing inside the expertise of enzymatic degradation maps.
  • Product profiles had been produced in high-throughput for arabinoxylan (AX)-active enzymes belonging to the glycoside hydrolase households GH43 (subfamilies 2 (MG432), 7 (MG437) and 28 (MG4328)) and GH8 (MG8) starting from twelve (arabino)xylo-oligosaccharides.
  • These enzymes had been discovered by way of sensible metagenomic analysis of faeces from the North American beaver (Castor canadensis). This work reveals how enzyme loading alters the product profiles produced by all enzymes studied and gives notion into AX degradation patterns revealing sequential substrate preferences of AX-active enzymes.
  • SignificanceArabinoxylan is very found inside the hemicellulosic fractions of rice straw, corn cobs and rice husk. Altering arabinoxylan into (arabino)xylo-oligosaccharides as added value merchandise which may be utilized in meals, feed, and cosmetics presents a sustainable and monetary completely different for the biorefinery industries. An atmosphere pleasant and worthwhile AX degradation requires a set of enzymes with particular traits.

As a result of this truth, enzyme discovery and analysis of substrate preferences is of utmost significance. Beavers, as buyers of woody biomass are a promising provide of a repertoire of enzymes able to deconstruct hemicelluloses into soluble oligosaccharides. Extreme-throughput analysis of oligosaccharide profiles produced by these enzymes will assist inside the assortment of most likely probably the most relevant enzymes for the biorefinery.

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