Tubulin modifying enzymes as goal for the therapy of tau-related ailments

Tubulin modifying enzymes as goal for the therapy of tau-related ailments

Tubulin modifying enzymes as aim for the remedy of tau-related illnesses

  • Inside the thoughts of victims with Alzheimer’s sickness (AD), the amount and dimension of microtubules (MTs) are significantly and selectively diminished. MTs are involved in a wide range of cell options, and defects of the microtubular system have emerged as a unifying hypothesis for the heterogeneous and variable medical exhibits of AD.
  • MTs orchestrate their fairly a couple of options by way of the spatiotemporal regulation of the binding of specialised microtubule-associated proteins (MAPs) and molecular motors. Covalent posttranslational modifications (PTMs) on the tubulin C-termini that protrude on the ground of MTs regulate the binding of these effectors.
  • In neurons, MAP tau may be very appreciable and its irregular dissociation from MTs inside the axon, cell mislocalization and hyperphosphorylation, are essential events leading to neuronal dying. Consequently, compounds concentrating on tau phosphorylation or aggregation are at current evaluated nevertheless their medical significance has not been demonstrated On this evaluation, we concentrate on the rising hyperlink between tubulin PTMs and tau dysfunction. In neurons, extreme ranges of glutamylation and detyrosination profoundly impression the physicochemical properties on the ground of MTs.
  • Moreover, in victims with early-onset progressive neurodegeneration, deleterious mutations in enzymes involved in modifying MTs on the ground have simply these days been acknowledged, underscoring the importance of this enzymatic gear in neurology. We postulate that pharmacologically concentrating on the tubulin-modifying enzymes holds promise as therapeutic technique for the remedy of neurodegenerative illnesses.

Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by concentrating on the essential enzymeMurA

Trivalent organoarsenicals equivalent to methylarsenite (MAs(III)) are considerably additional toxic than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) reveals essential antimicrobial train. Although MAs(III) and completely different organoarsenicals contribute to the worldwide arsenic biogeocycle, how they exert antibiotic-like properties is mainly unknown. To find out attainable targets of MAs(III), a genomic library of the gram-negative bacterium,

Shewanellaputrefaciens 200, was expressed in Escherichia coli with alternative for MAs(III) resistance. One clone contained the S. putrefaciensmurA gene (SpmurA), which catalyzes the first devoted step in peptidoglycan biosynthesis. Overexpression of SpmurA conferred MAs(III) resistance to E. coli.

Purified SpMurA was inhibited by MAs(III), phenylarsenite (PhAs(III)) or the phosphonate antibiotic fosfomycin nevertheless not by inorganic As(III). Fosfomycin inhibits MurA by binding to a conserved residue that corresponds to Cys117 in SpMurA. A C117D mutant was proof towards fosfomycin nevertheless remained delicate to MAs(III), indicating that the two compounds have completely completely different mechanisms of movement. New inhibitors of peptidoglycan biosynthesis are extraordinarily wished as antimicrobial treatment, and organoarsenicals characterize a new area for the occasion of novel compounds for combating the specter of antibiotic resistance.

nmr-spectrometers
nmr-spectrometers

Biochemistry of prenylated-FMN enzymes

  • The reversible (de)carboxylation of unsaturated carboxylic acids is carried out by the UbiX-UbiD system, ubiquitously present in microbes. The biochemical basis of this tough response has simply these days been uncovered by the invention of the UbiD cofactor, prenylated FMN (prFMN).
  • This carefully modified flavin is synthesized by the flavinprenyltransferaseUbiX, which catalyzes the non-metal dependent prenyl swap from dimethylallyl(pyro)phosphate (DMAP(P)) to the flavin N5 and C6 positions, making a fourth non-aromatic ring. Following prenylation, prFMN undergoes oxidative maturation to sort the iminium species required for UbiD train. prFMNiminium acts as a prostethic group and is definite by means of metal ion mediated interactions between UbiD and the prFMNiminium phosphate moiety.
  • The modified isoalloxazine ring is place adjoining to the E(D)-R-E UbiD signature sequent motif. The fungal ferulic acid decarboxylase Fdc from Aspergillus niger has emerged as a UbiD-model system, and has yielded atomic diploma notion into the prFMNiminium mediated (de)carboxylation. A wealth of knowledge now helps a mechanism reliant on reversible 1,Three dipolar cycloaddition between substrate and cofactor for this enzyme.
  • This poses the intriguing question whether or not or not an identical mechanism is utilized by all UbiD enzymes, significantly those that act as carboxylases on inherently more durable substrates equivalent to phenylphosphate or benzene/naphthalene. Definitely, considerable variability in the case of oligomerization, space motion and energetic website online development is now reported for the UbiD family.

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx008366
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-400ul 400 ul
EUR 627.6

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx031607-80l 80 µl
EUR 343.2

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

20-abx321167
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx329440
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

SUMO-activating enzyme subunit 1 (SAE1) Antibody

abx332268-100ul 100 ul
EUR 510

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx241829
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

SUMO-activating enzyme subunit 1 (SAE1) Antibody

20-abx241917
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx430292-200ul 200 ul
EUR 460.8

SUMO-Activating Enzyme Subunit 1 (SAE1) Antibody

abx237577-100ug 100 ug
EUR 610.8

Human SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx251614-96tests 96 tests
EUR 801.6

Cow SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520274-96tests 96 tests
EUR 1093.2

Mouse SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520276-96tests 96 tests
EUR 801.6

Rat SUMO-activating enzyme subunit 1 (SAE1) ELISA Kit

abx520277-96tests 96 tests
EUR 801.6

Human SAE1(SUMO-activating enzyme subunit 1) ELISA Kit

EH2266 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human SAE1/ SUMO-activating enzyme subunit 1 ELISA Kit

E2210Hu 1 Kit
EUR 685.2

Human SUMO- activating enzyme subunit 1, SAE1 ELISA KIT

ELI-39248h 96 Tests
EUR 988.8

Mouse SUMO- activating enzyme subunit 1, Sae1 ELISA KIT

ELI-41543m 96 Tests
EUR 1038

Bovine SUMO- activating enzyme subunit 1, SAE1 ELISA KIT

ELI-18883b 96 Tests
EUR 1113.6

Sae1 ELISA Kit| Mouse SUMO-activating enzyme subunit 1 ELISA Ki

EF016320 96 Tests
EUR 826.8

SAE1 ELISA Kit| Bovine SUMO-activating enzyme subunit 1 ELISA K

EF011944 96 Tests
EUR 826.8

Sae1 ELISA Kit| Rat SUMO-activating enzyme subunit 1 ELISA Kit

EF019390 96 Tests
EUR 826.8

SAE1 SUMO1 Activating Enzyme Subunit 1 Human Recombinant Protein

PROTQ9UBE0 Regular: 10ug
EUR 380.4
Description: SAE1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 378 amino acids (1-346 a.a.) and having a molecular mass of 42.2 kDa. The SAE1 is fused to 32 amino acid T7-Tag at N-terminus and purified by proprietary chromatographic techniques. _x000D_

SUMO-Activating Enzyme Subunit 1 (AOS1) Antibody

20-abx013214
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Human SUMO-activating enzyme subunit 2 (UBA2)

1-CSB-EP890664HU
  • EUR 524.40
  • EUR 285.60
  • EUR 1852.80
  • EUR 783.60
  • EUR 1234.80
  • EUR 355.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human SUMO-activating enzyme subunit 2(UBA2) expressed in E.coli

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-400ul 400 ul
EUR 627.6

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx025828-80l 80 µl
EUR 343.2

SUMO-Activating Enzyme Subunit 2 (SAE2) Antibody

abx430135-200ul 200 ul
EUR 460.8

ELISA kit for Human SUMO-activating enzyme subunit 1

EK4587 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human SUMO-activating enzyme subunit 1 in samples from serum, plasma, tissue homogenates and other biological fluids.

UBA2 Antibody / SUMO-activating enzyme subunit 2 / SAE2

RQ4241 100 ug
EUR 419

UBA2 Antibody / SUMO-activating enzyme subunit 2 / SAE2

RQ5505 100 ug
EUR 419

SUMO1 Activating Enzyme Subunit 1 (Recombinant)

20-abx073779
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Sumo1 Activating Enzyme Subunit 1 Antibody

20-abx115897
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Mouse SUMO- activating enzyme subunit 2, Uba2 ELISA KIT

ELI-39249m 96 Tests
EUR 1038

Human SUMO- activating enzyme subunit 2, UBA2 ELISA KIT

ELI-13499h 96 Tests
EUR 988.8

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03556 2µg Ask for price

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03557 10µg Ask for price

Recombinant Human SUMO1 Activating Enzyme Subunit 1

7-03558 1mg Ask for price

NEDD8 Activating Enzyme E1 Subunit 1 (Recombinant)

20-abx073743
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx003153
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx122107-100ug 100 ug
EUR 469.2

Nedd8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx114040
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-400ul 400 ul
EUR 627.6

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx033291-80l 80 µl
EUR 343.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-400ul 400 ul
EUR 627.6

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

abx027185-80l 80 µl
EUR 343.2

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx322625
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx213715
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibody

20-abx214286
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

NEDD8-Activating Enzyme E1 Catalytic Subunit (UBA3) Antibody

20-abx007000
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

NEDD8-Activating Enzyme E1 Catalytic Subunit (UBA3) Antibody

abx036612-100ug 100 ug
EUR 469.2

NEDD8-Activating Enzyme E1 Catalytic Subunit (UBA3) Antibody

20-abx320929
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

NAE1 NEDD8 Activating Enzyme E1 Subunit 1 Human Recombinant Protein

PROTQ13564 Regular: 10ug
EUR 380.4
Description: NAE1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 557 amino acids (1-534) and having a molecular mass of 62.7kDa.;NAE1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SAE1 Antibody

1-CSB-PA493084
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100

SAE1 Antibody

1-CSB-PA897667
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:15-1:50

SAE1 Antibody

1-CSB-PA883359ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

SAE1 Antibody

1-CSB-PA020666GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

SAE1 Antibody

1-CSB-PA004045
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

Human NEDD8-activating enzyme E1 catalytic subunit (UBA3) ELISA Kit

abx250401-96tests 96 tests
EUR 801.6

Mouse NEDD8-activating enzyme E1 catalytic subunit (UBA3) ELISA Kit

abx514736-96tests 96 tests
EUR 801.6

Rat NEDD8-activating enzyme E1 catalytic subunit (UBA3) ELISA Kit

abx514737-96tests 96 tests
EUR 801.6

Human UBA3(NEDD8-activating enzyme E1 catalytic subunit) ELISA Kit

EH1150 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human UBA3/ NEDD8-activating enzyme E1 catalytic subunit ELISA Kit

E2620Hu 1 Kit
EUR 685.2

Ubiquitin-like modifier-activating enzyme 1 Antibody

49197-100ul 100ul
EUR 399.6

Ubiquitin-like modifier-activating enzyme 1 Antibody

49197-50ul 50ul
EUR 286.8

UFM1 activating enzyme Recombinant Protein

92-228 0.05 mg
EUR 651.3
Description: UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. UBA5 is located primarily in cytoplasm, while it generally localizes to the nucleus in presence of SUMO2.

E1 Ubiquitin Activating Enzyme Antibody

DF13630 100ul
EUR 420

mlN4924 (NEDD8 activating enzyme inhibitor)

SIH-331-1MG 1 mg
EUR 1204.8
Description: The substance mlN4924 is a nedd8 activating enzyme inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is soluble in 10 mg/ml DMSO.

mlN4924 (NEDD8 activating enzyme inhibitor)

SIH-331-200UG 200 µg
EUR 374.4
Description: The substance mlN4924 is a nedd8 activating enzyme inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white powder which is soluble in 10 mg/ml DMSO.

Sae1/ Rat Sae1 ELISA Kit

ELI-53059r 96 Tests
EUR 1063.2

Human SUMO-conjugating enzyme UBC9 (UBE2I)

1-CSB-RP004744h
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human SUMO-conjugating enzyme UBC9(UBE2I),partial expressed in E.coli

ELISA kit for Chicken NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE30078-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Chicken NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Chicken NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE30078-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Chicken NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Chicken NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE30078-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Chicken NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE100527-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Rat NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE100527-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Rat NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE100527-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Rat NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE61391-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE61391-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human NEDD8-activating enzyme E1 regulatory subunit (NAE1)

KTE61391-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human NEDD8-activating enzyme E1 regulatory subunit (NAE1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

abx037966-100ug 100 ug
EUR 469.2

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx003250
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx008367
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx116488
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx126752
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx013243
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

abx028137-400ul 400 ul
EUR 627.6

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

abx028137-80l 80 µl
EUR 343.2

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

abx330573-100ul 100 ul
EUR 510

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx338621
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx242011
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx242036
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

20-abx324789
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx327721
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx214161
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody

20-abx214162
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Ubiquitin-Like 1-Activating Enzyme E1B (UBA2) Antibody

abx239143-100ug 100 ug
EUR 661.2

Ubiquitin-like modifier-activating enzyme 1 Conjugated Antibody

C49197 100ul
EUR 476.4

SAE1 Antibody

5749-002mg 0.02 mg
EUR 206.18
Description: SAE1 Antibody: Small ubiquitin-like modifiers (SUMOs) are a family of small, related proteins (SUMO-1/2/3/4) that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation, a major regulator of protein function in cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. This sumoylation is effected by the heterodimeric enzyme SAE1/SAE2 and the SUMO-1-conjugating enzyme Ubch9. The sumoylation pathway mediated by SAE1/SAE2 is distinct from other ubiquitin-like protein (Ubl) pathways.

SAE1 Antibody

5749-01mg 0.1 mg
EUR 523.7
Description: SAE1 Antibody: Small ubiquitin-like modifiers (SUMOs) are a family of small, related proteins (SUMO-1/2/3/4) that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation, a major regulator of protein function in cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. This sumoylation is effected by the heterodimeric enzyme SAE1/SAE2 and the SUMO-1-conjugating enzyme Ubch9. The sumoylation pathway mediated by SAE1/SAE2 is distinct from other ubiquitin-like protein (Ubl) pathways.

SAE1 Peptide

5749P 0.05 mg
EUR 197.7
Description: (CT) SAE1 peptide

SAE1 antibody

70R-50768 100 ul
EUR 292.8
Description: Purified Polyclonal SAE1 antibody

SAE1 antibody

70R-20073 50 ul
EUR 522
Description: Rabbit polyclonal SAE1 antibody

SAE1 antibody

70R-3589 50 ug
EUR 560.4
Description: Rabbit polyclonal SAE1 antibody raised against the N terminal of SAE1

SAE1 antibody

70R-3174 50 ug
EUR 560.4
Description: Rabbit polyclonal SAE1 antibody raised against the N terminal of SAE1

SAE1 antibody

70R-13557 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal SAE1 antibody

SAE1 Antibody

49894-100ul 100ul
EUR 399.6

SAE1 Antibody

49894-50ul 50ul
EUR 286.8

SAE1 Peptide

46-328P 0.1 mg
EUR 405.6
Description: SAE1 / AOS1 Peptide

SAE1 Antibody

36160-100ul 100ul
EUR 302.4

SAE1 antibody

10R-1641 50 ug
EUR 290.4
Description: Mouse monoclonal SAE1 antibody

SAE1 antibody

22850-100ul 100ul
EUR 468

SAE1 Antibody

25115-100ul 100ul
EUR 468

SAE1 siRNA

20-abx904767
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

SAE1 Antibody

CSB-PA794022-
EUR 402
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

SAE1 Antibody

CSB-PA794022-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against SAE1. Recognizes SAE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

SAE1 siRNA

20-abx932396
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

SAE1 siRNA

20-abx932397
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

anti-SAE1

YF-PA16682 50 ul
EUR 435.6
Description: Mouse polyclonal to SAE1

anti-SAE1

YF-PA16683 50 ug
EUR 435.6
Description: Mouse polyclonal to SAE1

anti-SAE1

YF-PA16684 100 ug
EUR 483.6
Description: Rabbit polyclonal to SAE1

pOTB7-SAE1

PVT18520 2 ug
EUR 277.2

SAE1 Antibody

F54771-0.08ML 0.08 ml
EUR 165

SAE1 Antibody

F54771-0.4ML 0.4 ml
EUR 379

SAE1 Antibody

R34751-100UG 100 ug
EUR 399

Human recombinant Ubiquitin Activating Enzyme E1

6429-50
EUR 542.4

Anti-Ubiquitin Activating Enzyme E1 Antibody

A02810 500ug
EUR 518.4
Description: Rabbit Polyclonal Ubiquitin Activating Enzyme E1 Antibody. Validated in IHC, WB and tested in Human.

Anti-Uba5/Ufm1 Activating Enzyme Antibody

A06385 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Uba5 Antibody (UBA5) detection.tested for WB in Human, Mouse, Rat.

UBA1 Antibody / E1 Ubiquitin activating enzyme

F54754-0.08ML 0.08 ml
EUR 165

UBA1 Antibody / E1 Ubiquitin activating enzyme

F54754-0.4ML 0.4 ml
EUR 379

SUMO-conjugating enzyme UBC9 Antibody

20-abx110241
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

pET28a- ULP (SUMO enzyme) Plasmid

PVT7015 2 ug
EUR 614.4

Anti-Angiotensin Converting Enzyme 1/ACE Antibody

PA2196-1 100ug/vial
EUR 400.8

Human Activating signal cointegrator 1 complex subunit 3 (ASCC3)

1-CSB-EP002198HU
  • EUR 524.40
  • EUR 285.60
  • EUR 1852.80
  • EUR 783.60
  • EUR 1234.80
  • EUR 355.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Activating signal cointegrator 1 complex subunit 3(ASCC3) expressed in E.coli

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody (HRP)

20-abx338233
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody (FITC)

20-abx338234
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ubiquitin Like Modifier Activating Enzyme 1 (UBA1) Antibody (Biotin)

20-abx338235
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rabbit Ubiquitin- like modifier- activating enzyme 1, UBA1 ELISA

ELI-28477Ra 96 Tests
EUR 1113.6

Mouse Trifunctional enzyme subunit alpha, mitochondrial (Hadha)

1-CSB-EP804834MO
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Trifunctional enzyme subunit alpha, mitochondrial(Hadha),partial expressed in E.coli

Mouse Trifunctional enzyme subunit beta, mitochondrial (Hadhb)

1-CSB-EP859963MO
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Trifunctional enzyme subunit beta, mitochondrial(Hadhb) expressed in E.coli

Human Trifunctional enzyme subunit beta, mitochondrial (HADHB)

1-CSB-RP030354h
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Trifunctional enzyme subunit beta, mitochondrial(HADHB),partial expressed in E.coli

Mouse Trifunctional enzyme subunit alpha, mitochondrial (Hadha)

1-CSB-BP804834MO
  • EUR 1008.00
  • EUR 398.40
  • EUR 2604.00
  • EUR 1362.00
  • EUR 1894.80
  • EUR 564.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Trifunctional enzyme subunit alpha, mitochondrial(Hadha),partial expressed in Baculovirus

Ubiquitin-Like Modifier Activating Enzyme 3 (Recombinant)

20-abx073328
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Ubiquitin-Like Modifier Activating Enzyme 5 (Recombinant)

20-abx073800
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

E1 Ubiquitin Activating Enzyme recombinant monoclonal antibody

A5836 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human E1 Ubiquitin Activating Enzyme for WB, IHC,ELISA

Goat E1/ubiquitin activating enzyme ELISA kit

E06E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E1/ubiquitin activating enzyme ELISA kit

E06E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E1/ubiquitin activating enzyme ELISA kit

E06E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E1/ubiquitin activating enzyme ELISA kit

E04E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E1/ubiquitin activating enzyme ELISA kit

E04E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E1/ubiquitin activating enzyme ELISA kit

E04E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E1/ubiquitin activating enzyme ELISA kit

E03E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E1/ubiquitin activating enzyme ELISA kit

E03E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E1/ubiquitin activating enzyme ELISA kit

E03E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E1/ubiquitin activating enzyme ELISA kit

E07E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E1/ubiquitin activating enzyme ELISA kit

E07E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E1/ubiquitin activating enzyme ELISA kit

E07E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E1/ubiquitin activating enzyme ELISA kit

E08E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E1/ubiquitin activating enzyme ELISA kit

E08E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E1/ubiquitin activating enzyme ELISA kit

E08E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E1/ubiquitin activating enzyme ELISA kit

E09E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E1/ubiquitin activating enzyme ELISA kit

E09E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E1/ubiquitin activating enzyme ELISA kit

E09E0115-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E1/ubiquitin activating enzyme ELISA kit

E02E0115-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E1/ubiquitin activating enzyme ELISA kit

E02E0115-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat E1/ubiquitin activating enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mapping enzyme-substrate interactions: its potential to assessment the mechanism of enzymes

With the rise of the need to make use of additional sustainable processes for the commerce in our society, the modeling of enzymes has flip into important to completely comprehend their mechanism of movement and use this info to enhance and design their properties. A great deal of methods to assessment enzymes computationally exist they often have been categorized on sequence-based, structure-based, and the additional new artificial intelligence-based ones.

Albeit the abundance of methods to help predict the carry out of an enzyme, molecular modeling is important when attempting to know the enzyme mechanism, as they function to correlate atomistic information with experimental info. Amongst them, methods that simulate the system dynamics at a molecular mechanics diploma of precept (classical strain fields) have confirmed to produce a whole analysis.

On this information chapter, we’ll analyze these strategies, emphasizing the importance of actual modeling of enzyme-substrate interactions. In the long term, a fast clarification of the transference of the information from evaluation analysis to the commerce is given accompanied with two examples of family enzymes the place their modeling has helped their exploitation.

Extreme-throughput expertise of product profiles for arabinoxylan-active enzymes from metagenomes

  • Metagenomics is an thrilling completely different to hunt for carbohydrate-active enzymes from a wide range of sources. Generally, metagenomics reveals dozens of putative catalysts that require sensible characterization for extra utility in industrial processes. Extreme-throughput screening methods applicable with sufficient pure substrates are important for an right sensible elucidation of substrate preferences.
  • Based mostly totally on DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) analysis of enzymatic response merchandise, we generated product profiles to consequently infer substrate cleavage positions, ensuing inside the expertise of enzymatic degradation maps.
  • Product profiles had been produced in high-throughput for arabinoxylan (AX)-active enzymes belonging to the glycoside hydrolase households GH43 (subfamilies 2 (MG432), 7 (MG437) and 28 (MG4328)) and GH8 (MG8) starting from twelve (arabino)xylo-oligosaccharides.
  • These enzymes had been discovered by way of sensible metagenomic analysis of faeces from the North American beaver (Castor canadensis). This work reveals how enzyme loading alters the product profiles produced by all enzymes studied and gives notion into AX degradation patterns revealing sequential substrate preferences of AX-active enzymes.
  • SignificanceArabinoxylan is very found inside the hemicellulosic fractions of rice straw, corn cobs and rice husk. Altering arabinoxylan into (arabino)xylo-oligosaccharides as added value merchandise which may be utilized in meals, feed, and cosmetics presents a sustainable and monetary completely different for the biorefinery industries. An atmosphere pleasant and worthwhile AX degradation requires a set of enzymes with particular traits.

As a result of this truth, enzyme discovery and analysis of substrate preferences is of utmost significance. Beavers, as buyers of woody biomass are a promising provide of a repertoire of enzymes able to deconstruct hemicelluloses into soluble oligosaccharides. Extreme-throughput analysis of oligosaccharide profiles produced by these enzymes will assist inside the assortment of most likely probably the most relevant enzymes for the biorefinery.

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